子宫动脉栓塞术(UAE)是一种用于治疗子宫肌瘤的微创介入疗法。根据提供的研究数据,UAE结合药物治疗在改善患者的月经情况和减少子宫肌瘤体积方面显示出显著效果。
治疗效果:研究表明,UAE结合药物治疗的患者在治疗后的下腹部疼痛发生率显著低于仅接受UAE治疗的对照组(5.0% vs 35.0%,P=0.018)。此外,治疗后月经周期显著缩短,尤其是在治疗后6个月和12个月时,研究组的月经期明显短于对照组。
肌瘤体积变化:治疗后,子宫肌瘤的体积显著缩小,尤其是在治疗后3、6和12个月时,研究组的肌瘤体积均小于对照组。这表明UAE结合药物治疗在减少肌瘤体积方面具有更好的效果。
MRI评估:MRI在UAE前后对肌瘤的疗效评估中具有重要意义。术后3、6、12个月的复查显示,肌瘤的T2WI信号明显降低,部分肌瘤的T1WI信号增高,肌瘤体积呈进行性缩小。
综上所述,UAE结合药物治疗在改善子宫肌瘤患者的月经情况和减少肌瘤体积方面具有显著的疗效,并能有效缓解UAE引起的下腹部疼痛。然而,由于样本量较小,仍需多中心、大样本的随机对照试验进一步确认其疗效。
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